Open AccessThe Pharmacology of p ‐Aminopropiophenone in the Detoxification of Cyanide
Author(s) -
Baskin Steven I.,
Fricke Robert F.
Publication year - 1992
Publication title -
cardiovascular drug reviews
Language(s) - English
Resource type - Journals
eISSN - 1527-3466
pISSN - 0897-5957
DOI - 10.1111/j.1527-3466.1992.tb00256.x
Subject(s) - reprint , library science , operations research , medicine , classics , engineering , physics , history , computer science , astronomy
: PAPP is effective as a pretreatment antidote to cyanide when used by single-dose administration. Further experiments need to be performed to establish a lack of toxicity of PAPP in multiple-dose experiments. Possible chronic hematological and genotoxic effects of PAPP may limit its development in repeated chronic treatment. Combination therapy of a prophylactic sulfur donor with a low dose of a safer prophylactic aminophenone (e.g., PAOP or p- aminoheptanoylphenone or their N-hydroxy metabolites) may provide more efficacious protection against cyanide than PAPP. This combination could allow for a reduction in the dosage of MetHb formers that would reduce the chance of unwanted side effects of the employed therapeutic compounds.