Open AccessQuantitative Assessment of Neuronal Damage in a Transgenic Murine Model of Alzheimer's Disease
Author(s) -
Mervis Ronald F.,
McKeon Jody,
Pindell Timothy,
Campbell Deborah,
Lieberburg Ivan,
Schenk Dale,
Kahn Karen,
Games Dora
Publication year - 1999
Publication title -
cns drug reviews
Language(s) - English
Resource type - Journals
eISSN - 1527-3458
pISSN - 1080-563X
DOI - 10.1111/j.1527-3458.1999.tb00133.x
Subject(s) - hippocampal formation , entorhinal cortex , neuroscience , genetically modified mouse , hippocampus , atrophy , transgene , alzheimer's disease , disease , medicine , biology , pathology , biochemistry , gene
Summary : Our findings are in general agreement with previous studies of hippocampal dendritic atrophy in AD brains. Moreover, since these hippocampal neurons receive afferent innervation from the entorhinal cortex and this latter region is widely damaged in AD, our results suggest that amyloid deposition and partial deafferentiation of enorhinal input may both contribute to hippocampal damage with concomitant disruption of brain circuitry. These findings support the use of these PD‐APP mice which overexpress amyloid as an animal model of AD. It also serves as validation to the efficacy and sensitivity of quantitative Golgi studies for assessing the extent of neuronal damage and, subsequently, for testing the efficacy of various treatment strategies. (This study was supported by Elan Pharmaceuticals)