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Body Mass Index and Adult Weight Gain Among Reproductive Age Women With Migraine
Author(s) -
Vo Michelle,
Ainalem Abinnet,
Qiu Chunfang,
Peterlin B. Lee,
Aurora Sheena K.,
Williams Michelle A.
Publication year - 2011
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.2010.01833.x
Subject(s) - medicine , migraine , odds ratio , body mass index , overweight , obesity , epidemiology , weight gain , pregnancy , obstetrics , body weight , biology , genetics
( Headache 2011;51:559‐569) Objective.— To evaluate the cross‐sectional relationship between migraine and pregravid obesity; and to assess the risk of adult weight gain among women with history of a pediatric diagnosis of migraine. Background.— Obesity, comorbid with pain disorders including migraine, shares common pathophysiological characteristics including systemic inflammation, and derangements in adipose‐tissue derived cytokines. Despite biochemical and epidemiological commonalities, obesity–migraine associations have been inconsistently observed. Methods.— A cohort of 3733 women was interviewed during early pregnancy. We ascertained participants' self‐reported history of physician‐diagnosed migraine and collected self‐reported information about pregravid weight, adult height, and net weight change from age 18 to the 3‐months period before pregnancy. Using pregravid body mass index, we categorized participants as follows: lean (<18.5 kg/m 2 ), normal (18.5‐24.9 kg/m 2 ), overweight (25‐29.9 kg/m 2 ), obese (30‐34.9 kg/m 2 ), severely obese (35‐39.9 kg/m 2 ), and morbidly obese (≥40 kg/m 2 ). Logistic regression procedures were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results.— After adjusting for confounders, relative to normal weight women, obese women had a 1.48‐fold increased odds of migraine (OR = 1.48; 95% CI 1.12‐1.96). Severely obese (OR = 2.07; 95% CI 1.27‐3.39) and morbidly obese (OR = 2.75; 95% CI 1.60‐4.70) had the highest odds of migraines. Women with a history of diagnosed pediatric migraine had a 1.67‐fold higher odds of gaining ≥10.0 kg above their weight at age 18, as compared with non‐migraineurs (OR = 1.67; 95% CI 1.13‐2.47). Conclusion.— These data support earlier observations of migraine–obesity association among women, and extend the literature to include evidence of adult weight gain among women with a history of pediatric migraine.