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Reversible Cerebral Vasoconstriction Phenomena Following Indomethacin Administration
Author(s) -
Lambru Giorgio,
Manzoni Gian Camillo,
Torelli Paola,
Grisendi Ilaria,
Zanferrari Carla
Publication year - 2011
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.2010.01803.x
Subject(s) - reversible cerebral vasoconstriction syndrome , vasoconstriction , medicine , administration (probate law) , anesthesia , cerebral circulation , cardiology , business , political science , law
We report a case of reversible cerebral vasoconstriction, possibly secondary to the use of indomethacin to relieve pain during a migraine with aura attack. Non‐steroidal anti‐inflammatory drugs are not reported among substances precipitating secondary forms of reversible cerebral vasoconstriction. A transcranial Doppler sonography study, performed during the phase with headache and the other neurological deficits, suggested the presence of distal cerebral vasospasm, which normalized when all symptoms regressed completely (<24 hours). We speculated that indomethacin might represent the trigger factor of these particular phenomena, by acting either directly on distal cerebral vessels, or under certain predisposing conditions, such as migraine with aura attacks.