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The Effect of Prophylactic Medications on TMS for Migraine Aura
Author(s) -
Almaraz Amy C.,
Dilli Esma,
Dodick David W
Publication year - 2010
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.2010.01787.x
Subject(s) - transcranial magnetic stimulation , migraine , aura , medicine , anesthesia , cortical spreading depression , migraine with aura , randomized controlled trial , stimulation
Purpose.— Low frequency transcranial magnetic stimulation (TMS) has recently been shown to be effective for the acute treatment of migraine with aura. TMS has recently been shown to inhibit cortical spreading depression (CSD). Prophylactic medications (PM) may reduce the frequency of migraine attacks by elevating CSD threshold. The interaction between PM and TMS is unknown. Methods.— Subgroup analysis was performed on a double‐blind, Sham‐controlled study that evaluated the efficacy and safety of TMS for the acute treatment of migraine with aura. Analysis of the primary efficacy endpoint pain‐free at 2 hours (pain‐free rate [PFR]) between TMS and Sham groups was performed based on the non‐randomized use of PM. Results.— A total of 164 subjects eligibly treated at least 1 migraine with aura attack with TMS (n = 82) or Sham stimulation (n = 82). Baseline pain intensity at the time of treatment for the first attack was no pain (31%), mild (40%), moderate (23%), or severe pain (6%). PM were used by 37% (31/82) and 41.5% (34/82) in the Sham‐ and TMS‐treated patients, respectively. Sham patients on no PM (Sham without) had significantly higher PFR than Sham‐treated patients on PM (Sham with) ( P = .0014). There was no difference in PFR between TMS‐treated patients on (TMS with) or off (TMS without) PM ( P = .5513). However, TMS with had significantly higher PFR than Sham with patients ( P = .002). There was no difference in PFR between TMS without and Sham without patients ( P = .4061). Conclusion.— Prophylactic medications do not appear to influence the treatment response to TMS. The better response in Sham‐treated patients not on PM may indicate a more responsive subgroup or different patient phenotype than those currently using PM. These findings will need to be verified in a larger patient sample randomized by presence or absence of PM.