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Spontaneous Intracranial Hypotension‐Hypovolemia Associated With Tacrolimus
Author(s) -
Ahn Andrew H.,
Berman Brian D.,
Dillon William P.
Publication year - 2010
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.2010.01701.x
Subject(s) - hypovolemia , medicine , tacrolimus , orthostatic vital signs , anesthesia , cerebrospinal fluid , intracranial hypotension , spontaneous intracranial hypotension , cerebrospinal fluid pressure , intracranial pressure , blood pressure , transplantation
There is little precedent for a medication‐induced spontaneous intracranial hypotension/cerebrospinal fluid (CSF) hypovolemia (SIH). This case history of a woman with low CSF pressure, orthostatic headache, and radiographic findings consistent with SIH but without a detectable leak was notable for its association, both onset and resolution, with the use of the calcineurin inhibitor tacrolimus (FK506). A literature review for potential causes of a tacrolimus‐induced CSF hypotension suggests many potential mechanisms of action, including effects on blood brain barrier and dural compliance, and supports further vigilance for this condition in the medically complex setting of tacrolimus use.