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Headache in Thrombotic Thrombocytopenic Purpura: Two Cases With Pathophysiological Considerations
Author(s) -
Bezov David,
Lipton Richard B.,
Podoltsev Nikolai,
Zhao Chi G.,
Ashina Sait
Publication year - 2010
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.2010.01680.x
Subject(s) - thrombotic thrombocytopenic purpura , pathophysiology , medicine , migraine , platelet , pediatrics , dermatology
Headache is one of the most common neurological symptoms reported by patients with thrombotic thrombocytopenic purpura (TTP). Reports of headache characteristics in patients with TTP are rare. We report 2 cases of headache in a setting of TTP and review previous reports. Headache in TTP can have features in common with both migraine and tension‐type headache. Although the pathophysiology of headache in TTP is not certain, platelet aggregation and activation may play a key role.