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Partially Reversible Cortical Metabolic Dysfunction in Familial Hemiplegic Migraine With Prolonged Aura
Author(s) -
Guedj Eric,
Belenotti Pauline,
Serratrice Jacques,
Ene Nicoleta,
Pineau Sandrine,
Donnet Anne,
Mundler Olivier,
Weiller PierreJean
Publication year - 2010
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.2010.01634.x
Subject(s) - familial hemiplegic migraine , cerebral blood flow , aura , migraine with aura , migraine , medicine , cardiology , anesthesia
We report a SPECT and PET voxel‐based analysis of cerebral blood flow and metabolic rate for glucose in a 23‐year‐old woman with familial hemiplegic migraine (FHM) caused by ATP1A2 gene mutation. In comparison with healthy subjects, a PET scan showed brain glucose hypometabolism, controlaterally to the hemiplegia, in the perisylvian area early in the attack (Day 1), without any SPECT perfusion abnormalities. Decrease in metabolic rate was only partially reversible at Day 78, concordant at this time with a remaining hemisensory loss. These findings provide further evidence for a primary cortical metabolic dysfunction in FHM.