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Single Nucleotide Polymorphisms of the Serotonin Transporter Gene in Migraine – An Association Study
Author(s) -
Bayerer Bettina,
Engelbergs Jörg,
Savidou Irini,
Boes Tanja,
Küper Michael,
Schorn Christoph F.,
Wissmann Andreas,
Knop Dietmar,
Diener Hans C.,
Limmroth Volker
Publication year - 2010
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.2009.01553.x
Subject(s) - migraine , allele , aura , serotonin transporter , single nucleotide polymorphism , migraine with aura , genetics , phenotype , gene , etiology , genetic association , 5 httlpr , medicine , biology , genotype , polymorphism (computer science)
We report a case–control study with 251 unrelated migraine patients and 192 unrelated healthy controls to evaluate an association between the polymorphisms of the 5‐HT transporter (5‐HTT) gene rs2066713 and rs1979572 and different migraine phenotypes. We found a genetic association for the A allele of rs1979572 for migraine with aura (MA) especially in women as well as a significant lower prevalence for MA for carrier of the A allele of rs2066713 in women. These findings support previous results suggesting that the 5‐HTT gene is involved in the polygenic etiology of MA. These data further suggest that women are more likely to be clinically affected by mutations in the 5‐HTT gene than men.