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Common CX3CR1 Alleles Are Associated With a Reduced Risk of Headaches
Author(s) -
Combadière Christophe,
Godin Ophelia,
Vidal Cécile,
Cangialosi Arnaud,
Proust Carole,
Tzourio Christophe
Publication year - 2008
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.2007.01011.x
Subject(s) - headaches , odds ratio , cx3cr1 , allele , confidence interval , medicine , migraine , haplotype , population , gastroenterology , chemokine receptor , genetics , biology , chemokine , receptor , surgery , gene , environmental health
Objectives.— The aim of this study was to investigate the role of the chemokine receptor CX3CR1 in headaches and migraine. Methods.— Distribution of 2 polymorphisms of the chemokine receptor CX3CR1 (V249I and T280M) was determined in a population‐based sample of 1179 elderly individuals. Results.— Heterozygotes for both CX3CR1 polymorphisms had a reduced risk of recurrent headaches, with an odds ratio (OR) of 0.64 (95% confidence interval [CI] = 0.46‐0.90) for the I249 allele and 0.55 (95% CI = 0.38‐0.81) for the M280 allele. Haplotype analysis showed that carriers of the rarer CX3CR1 I249‐M280 haplotype had a reduced risk of recurrent headaches, with an OR of 0.57 (95% CI = 0.41‐0.80, P = .001). This association was seen for both nonmigraine headaches (OR = 0.47, 95% CI = 0.28‐0.79, P = .004) and migraine (OR = 0.65, 95% CI = 0.43‐0.98, P = .041). Conclusions.— These results need to be replicated but suggest that the chemokine receptor CX3CR1 may play a role in recurrent headaches.