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Cortical Spreading Depression and Estrogen
Author(s) -
EikermannHaerter Katharina,
Kudo Chiho,
Moskowitz Michael A.
Publication year - 2007
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.2007.00818.x
Subject(s) - cortical spreading depression , aura , migraine , migraine with aura , neuroscience , electrophysiology , depression (economics) , psychology , medicine , economics , macroeconomics
Cortical spreading depression (CSD) is an electrophysiological phenomenon characterized by a wave of excitation followed by inhibition. The aura phase that precedes migraine headache in about 20‐30% of migraineurs shares overlapping characteristics with CSD. Studies of rare autosomal‐dominant forms of migraine with aura provide strong evidence that the threshold for evoking CSD and aura are related to neuronal excitability. Although the relationship between CSD and migraine without aura is not completely understood, the molecular abnormalities that predispose to migraine with aura illustrate the importance of physiologic events associated with neuronal hyperexcitability, and provide a basis for understanding a more generalized view of migraine.