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Pathophysiology of Headache—Past and Present
Author(s) -
Moskowitz Michael A.
Publication year - 2007
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.2007.00678.x
Subject(s) - citation , library science , associate editor , classics , medicine , psychoanalysis , art history , psychology , history , computer science
In 1979 my laboratory published its first article on migraine in The Lancet, and it was entitled “Neurotransmitters and the fifth cranial nerve: Is there a relation to the headache phase of migraine?”1 In this article, we hypothesized that the trigeminal nerve was a critical component in the pathogenesis of migraine. At that time, the sensory innervation to the blood vessels of the circle of Willis was unknown. We believed that such a pathway, if it existed, may contain vasoactive neuropeptides such as substance P which would be released into the meninges. Because hemicranial pain was so prevalent in many migraineurs, we wondered whether or not peptide neurotransmitters might be implicated in an ipsilaterally projecting pathway from the trigeminal ganglia to the meninges and its blood vessels.