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The Serotonin Syndrome, Triptans, and the Potential for Drug–Drug Interactions
Author(s) -
Shapiro Robert E.,
Tepper Stewart J.
Publication year - 2007
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.2006.00691.x
Subject(s) - triptans , serotonin syndrome , serotonergic , food and drug administration , medicine , drug , serotonin , migraine , concomitant , pharmacology , intensive care medicine , adverse effect , anesthesia , receptor
The serotonin syndrome is an acute adverse reaction to medications that enhance serotonergic activity. The severity of cases ranges from mild to fatal. Recently, the U.S. Food and Drug Administration issued an alert that the risk of developing serotonin syndrome may be increased by the concomitant administration of triptan medications with certain other medications. However, a review of published data does not allow an accurate assessment of such risks related to triptans. We conclude that it is currently unclear whether administration of triptans with other serotonergic medications increases the risk of serotonin syndrome.