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Serotonin Transporter Gene Polymorphism and Migraine in the Korean Population
Author(s) -
Kim WooKyung,
Kim HyunSook,
Kim WonJoo,
Lee KyungYul,
Park Hyojin,
Kim ChanHyung,
Kim Se Joo,
Choi YoungChul
Publication year - 2005
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.2005.05187.x
Subject(s) - serotonin transporter , migraine , genotype , allele , serotonin , 5 httlpr , medicine , endocrinology , polymorphism (computer science) , genetics , population , biology , gene , receptor , environmental health
Objective.—To evaluate the association between a serotonin (5‐HT) transporter gene polymorphism and migraines in Koreans. Background.—The 5‐HT metabolism is believed to play an important part in the pathophysiology of migraines, and a polymorphism of the serotonin transporter (5‐HTT) promoter region might influence 5‐HTT expression and serotonin uptake. Methods.—This study compared 52 patients with migraine and 170 healthy control subjects in order to determine the association between a polymorphism of the 5‐HTT gene‐linked polymorphic region (5‐HTTLPR) and migraine. Using PCR techniques, the products of the 484‐base pair (bp) fragments were denoted as being short alleles (s) and those of 528 bp as being long (l). Results.—The genotype distribution of the healthy controls was s/s (56.5%), s/l (38.2%), and l/l (5.3%) and that of the patients with migraine was 65.4%, 30.8%, and 3.8%, respectively. No significant differences were noted in the genotype and allele frequencies of 5‐HTTLPR between the patients with migraine and the control subjects. Conclusions.—A 5‐HTTLPR polymorphism does not appear to be involved in the genetic predisposition to migraines.