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Clomiphene Citrate as a New Treatment for SUNCT: Hormonal Manipulation for Hypothalamic‐Influenced Trigeminal Autonomic Cephalalgias
Author(s) -
Rozen Todd D.,
Saper Joel R.,
Sheftell Fred D.,
Dodick David W.
Publication year - 2005
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.2005.05143_2.x
Subject(s) - medicine , endocrinology , anesthesia
We present a patient with treatment refractory short‐lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) who was found to have low levels of serum testosterone supporting the hypothalamic connection to this trigeminal autonomic cephalalgia. Clomiphene citrate therapy induced a significant elevation of testosterone levels (by its effect on hypothalamic estrogen receptors) and led to a dramatic reduction in SUNCT attacks. Hormonal manipulation may be a treatment strategy for hypothalamic‐influenced trigeminal autonomic cephalalgias.