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Serum S100β Protein in Children With Acute Recurrent Headache: A Potentially Useful Marker for Migraine
Author(s) -
Papandreou Ourania,
Soldatou Alexandra,
Tsitsika Artemis,
Kariyannis Catherine,
Papandreou Thalia,
Zachariadi Asimina,
Papassotiriou Ioannis,
P. Chrousos George
Publication year - 2005
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.2005.00263.x
Subject(s) - migraine , medicine , acute migraine , tension headache , pediatrics , immunology , pathology , alternative medicine , placebo
Objective.—To examine the role of glia‐derived S100β protein and to evaluate its use as a biochemical marker in childhood acute recurrent headache. Methods.—Twenty‐five patients with acute recurrent headache (according to International Headache Society criteria) from our department's Headache Clinic were studied. Blood samples for measurement of serum S100β were drawn: (1) ≤3‐hour post pain attack from our patients and (2) from 23 healthy controls. Results.—Of the 25 patients evaluated, 15 suffered from migraine and 10 from tension‐type headache (TTH). Statistical analysis of the mean values of S100β levels demonstrated a significant elevation in children with migraine headache, with values higher than those of both children with TTH and controls ( P = .001). Conclusions.—Our data suggest a direct relation between childhood migraine attacks and increased production of glial S100β protein. Serum S100β determination may be a useful biochemical marker for migraine in acute recurrent headache in childhood.