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Rizatriptan 10‐mg Wafer Versus Usual Nontriptan Therapy for Migraine: Analysis of Return to Function and Patient Preference
Author(s) -
Pascual Julio,
GarcíaMoncó Carlos,
Roig Carles,
Yusta Izquierdo Antonio,
LópezGil Arturo
Publication year - 2005
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.2005.00237.x
Subject(s) - rizatriptan , medicine , migraine , confidence interval , hazard ratio , odds ratio , anesthesia , sumatriptan , receptor , agonist
Background.—More than half of patients with migraine suffer moderate to severe functional disability during migraine attacks. Objective.—To compare effects on functional disability at 2 hours after treating a migraine with rizatriptan 10‐mg wafer versus usual nontriptan therapy for triptan‐naïve patients with migraine. Design.—Open‐label, prospective, two‐attack study conducted at 111 neurology clinics. Methods.—Adult patients with migraine treated two migraine attacks, the first with their usual nontriptan therapy (nonsteroidal anti‐inflammatory drugs, 57%; analgesics, 27%; or ergot derivatives, 16%) and the second with rizatriptan 10‐mg wafer. Patients recorded pain intensity and functional disability at the start, and functional disability at 2 hours, as well as the time of return to normal function. Results.—A total of 1353 patients, 76% of them female, completed the study and were considered evaluable. During first and second migraine attacks, 55% and 63% of patients, respectively, reported severe disability or requiring bed rest. At 2 hours after treatment, the likelihood of experiencing any disability was more than five times greater after usual nontriptan therapy than after rizatriptan (odds ratio, 5.68; 95% confidence interval (CI), 4.66 to 6.94; P < .001). Rizatriptan was twice as likely to return patients to normal function than usual nontriptan therapy after adjusting for confounding factors (adjusted hazard ratio, 2.08; 95% CI, 1.92 to 2.25; P < .001). Assessed over all time points up to 6 hours, the speed of return to normal function was 52% faster after rizatriptan therapy ( P < .001). Significantly more patients preferred rizatriptan than usual nontriptan therapy (78.8% vs. 21.2%; P < .001). The most common reasons cited for preference for rizatriptan were faster relief of headache pain and faster return to normal function. Conclusions.—Patients in this study were more likely to experience a return to normal function at 2 hours after receiving rizatriptan than after their usual nontriptan therapy for migraine. The results of this study, using patient‐oriented, clinically relevant endpoints such as functional disability and preference, will help to guide practitioners in making recommendations for acute migraine treatment.