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Familial Migraine With Aura: Association Study With 5‐HT 1B/1D , 5‐HT 2C , and hSERT Polymorphisms
Author(s) -
Racchi Marco,
Leone Massimo,
Porrello Emanuela,
Rigamonti Andrea,
Govoni Stefano,
Sironi Marita,
Montomoli Cristina,
Bussone Gennaro
Publication year - 2004
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.2004.04072.x
Subject(s) - aura , 5 ht receptor , association (psychology) , migraine , migraine with aura , medicine , psychology , serotonin , receptor , psychotherapist
Background.—The serotonergic system has a significant role in the pathophysiology and pharmacology of migraine. Objective.—To study the association between the occurrence of migraine with aura and 5‐HT 1B/1D and 5‐HT 2C receptor gene and the human serotonin transporter (hSERT) gene polymorphisms in 18 unrelated families with multiple affected members. Method.—Two polymorphisms in the 5‐HT 1B/1D receptor gene and one polymorphism in the 5‐HT 2C receptor gene were studied by restriction fragment length polymorphism analysis. Allelic variation of the hSERT, with 9, 10, and 12 copies of a “repetitive element,” was studied by polymerase chain reaction amplification of the variable number tandem repeat region. Results.—Allelic distribution of 5‐HT 1B/1D and 5‐HT 2C receptor gene polymorphisms in affected patients did not differ in either of the control groups (unaffected relatives or unrelated healthy individuals). A trend toward a significant effect of the 12‐repeat hSERT allele as a risk factor for migraine with aura versus unrelated controls was observed. Conclusion.—Our data do not support the involvement of 5‐HT 1B/1D and 5‐HT 2C receptor gene polymorphisms in migraine with aura, yet do suggest a possible role for a locus at or near the hSERT gene in the susceptibility to migraine with aura.