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Dopamine Hypersensitivity in Migraine: Role in Apomorphine Syncope
Author(s) -
Zompo Maria,
Lai Marina,
Loi Vincenzo,
Pisano Maria Rosaria
Publication year - 1995
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1995.hed3504222.x
Subject(s) - apomorphine , dopaminergic , medicine , migraine , dopamine , dopamine agonist , aura , agonist , dopamine receptor , anesthesia , neuroscience , psychology , receptor
There is some evidence supporting a potential role of hypersensitivity of the dopaminergic system in the pathogenesis of migraine. In this case report, we describe a syncopal episode in a patient with migraine without aura after the administration of a very low dose of apomorphine, a classical agonist of dopaminergic receptors. The absence of cardiovascular risk factors in this patient suggests that the clinical event might have been caused by hypersensitivity of the dopaminergic system.