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Video Assessment of Yawning Induced by Sublingual Apomorphine in Migraine
Author(s) -
Bene Enrico,
Poggioni Marco,
Tommasi Francesco
Publication year - 1994
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1994.hed3409536.x
Subject(s) - apomorphine , migraine , placebo , dopamine agonist , dopaminergic , agonist , stimulation , medicine , dopamine , dopamine receptor , anesthesia , psychology , receptor , alternative medicine , pathology
SYNOPSIS A double‐blind, placebo‐controlled study was carried out in 14 migraineous outpatients and 8 control subjects to assess yawning response to 0.25 mg of sublingual apomorphine, a dopamine receptor agonist, by means of an audiovisual technique. Apomorphine induced a significantly higher number of yawns than placebo in both groups of subjects, but the effect was significantly greater in migraine sufferers than in controls. The result seems to confirm the previous reported hyper‐responsiveness to pharmacological dopaminergic stimulation in migraine sufferers. Moreover, the audiovisual technique seems to be an appropriate tool to study yawning response in man.