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Plasma Monoamines in Tension‐Type Headache
Author(s) -
Castillo J.,
Martínez F.,
Leira R,
Lema M.,
Noya M.
Publication year - 1994
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1994.hed3409531.x
Subject(s) - monoaminergic , monoamine neurotransmitter , norepinephrine , epinephrine , dopamine , medicine , catecholamine , serotonin , pathophysiology , endocrinology , depression (economics) , anesthesia , receptor , economics , macroeconomics
SYNOPSIS Clinical and pharmacological data suggest a derangement of central monoaminergic systems in tension‐type headache. Biochemical evidence has been rarely recognized. These findings may relate with pathophysiological mechanisms of headache or with underlying depression. We measured platelet‐rich plasma serotonin and plasma catecholamines (norepinephrine, epinephrine, and dopamine) in 30 patients with tension‐type headache and in 20 healthy controls, using High‐Pressure Liquid Chromatography. We studied differences between groups and the relation between biochemical parameters and clinical indices evaluating duration and severity of headache and depression. Platelet serotonin levels in tension headache patients were higher than in controls ( P <0.001). Plasma catecholamine levels were lower in patients than in controls ( P