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Substance P: Correlation of CSF and Plasma Levels
Author(s) -
Clark Jeffrey W.,
Senanayake Preenie,
Solomon Glen D.,
Gallagher Claudia
Publication year - 1994
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1994.hed3405261.x
Subject(s) - cerebrospinal fluid , substance p , radioimmunoassay , lumbar puncture , medicine , correlation , plasma levels , spearman's rank correlation coefficient , positive correlation , endocrinology , chemistry , neuropeptide , mathematics , statistics , receptor , geometry
SYNOPSIS Objective: To determine the correlation between cerebrospinal fluid and plasma concentrations of substance P.Patients: 37 patients undergoing lumbar puncture for various diagnostic purposes. Measurements: Samples of cerebrospinal fluid and blood were obtained at the same visit. Substance P was measured by radioimmunoassay technique. At least 4 separate measurements were conducted on each sample to insure accuracy. Results: The mean plasma SP level was 1.195 (± 1.1). The mean cerebrospinal fluid substance P level was 1.075 (± .07). There was a statistically significant positive correlation between substance P level in the plasma and cerebrospinal fluid. The Pearson correlation coefficient was 0.656 (P<.0001) and the Spearman correlationcoefficient was 0.698 (P<.0001). Conclusions: Plasma substance P levels closely correlate with cerebrospinal fluid substance P levels. This will simplify the measurement of substance P in the evaluation of therapeutic agents for headache.