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Disruption of the Immunopeptidergic Network in Dietary Migraine
Author(s) -
Martelletti Paolo,
Stirparo Giuseppe,
Rinaldi Cristina,
Frati Luigi,
Giacovazzo Mario
Publication year - 1993
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1993.hed3310524.x
Subject(s) - migraine , cytokine , acute migraine , interleukin 1β , medicine , interleukin 6 , interleukin , immunology , endocrinology , pathology , alternative medicine , placebo
SYNOPSIS This investigation is devoted to the study of the time‐course of a cytokines panel (IL‐4, IL‐6, IFN‐gamma,GM‐CSF) in plasma samples from migraine patients. The data obtained during challenged migraine crises was compared to the baseline values. Time‐data series analysis showed a fall after a challenge test for IL‐4 and IL‐6 plasma levels and an opposite trend for gamma‐IFN and GM‐CSF levels. The implication of this phenomenon in dietary migraine is not readily evident. There may possibly be an activation of this cytokine network together with the well‐known impairment in the neuropeptidergic system, consideringthe close links between interleukins and other cytokines and the neuro‐mediators of pain, such ashistamine and 5‐HT.