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Migraine Without Aura and Reproductive Life Events: A Clinical Epidemiological Study in 1300 Women
Author(s) -
Granella Franco,
Sances Grazia,
Zanferrari Carla,
Costa Alfredo,
Martigi Emilia,
Manzoni Gian Camillo
Publication year - 1993
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1993.hed3307385.x
Subject(s) - migraine , aura , menarche , menstruation , medicine , pregnancy , epidemiology , migraine with aura , pill , pediatrics , obstetrics , psychiatry , biology , pharmacology , genetics
SYNOPSIS A retrospective study was conducted on 1300 women suffering from migraine without aura referred to the Headache Centers of Parma and Pavia from 1984 to 1990. All the data concerning their reproductive life, and the modifications induced by it on the course of headache were obtained from record‐charts. Migraine frequently started at menarche (10.7%); in 60% of cases the migraine attacks occurred mostly or exclusively in the perimenstrual period, in 67% of cases disappeared during pregnancy, and in 24.1% significantly (P<0.0001) worsened with “pill” intake. This study also designated a migraine subgroup which is more influenced by changes in sexual hormones, i.e. migraine with onset at menarche. This form of migraine shows more frequently a menstrual periodicity, and usually improves during pregnancy. Furthermore, menstrual migraine patients show social and cultural characteristics which distinguish them from other women.