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Reduced Sensitivity of Lymphocyte Beta‐Adrenergic Receptors in Migraine
Author(s) -
Kuritzky A.,
Bennet E.,
Hering R.,
Ebstein R.
Publication year - 1993
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1993.hed33040198.x
Subject(s) - adrenergic receptor , receptor , migraine , lymphocyte , adrenergic , beta (programming language) , sensitivity (control systems) , medicine , endocrinology , neuroscience , chemistry , biology , computer science , engineering , programming language , electronic engineering
SYNOPSIS Cyclic AMP(CAMP) accumulation induced by isoproterenol (IP) and forskolin in intact lymphocytes was determined in 12 patients with migraine and 12 healthy controls. Our data showed that IP CAMP accumulation (8.20 + 1.08 Pmol/million cells) was significantly ( P = 0.033) lower than accumulation in the controls (14.39 + 2.44 Pmol/million cells). Forskolin‐induced CAMP did not differ in the two groups. These findings support the association of migraine and a reduced lymphocyte beta‐adrenergic receptor sensitivity. An alteration in lymphocyte beta‐adrenergic receptor may reflect similar changes in central beta‐adrenergic function and may be used as a probe to evaluate its activity.