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Treatment of Acute Migraine Attack With Diclofenac Sodium: A Double‐Blind Study
Author(s) -
Karachalios George N.,
Fotiadou Adroniki,
Chrisikos Nickolaos,
Karabetsos Alexandros,
Kehagioglou Kyriakos
Publication year - 1992
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1992.hed3202098.x
Subject(s) - diclofenac sodium , medicine , diclofenac , migraine , anesthesia , placebo , intramuscular injection , acute migraine , pain relief , double blind , pharmacology , alternative medicine , pathology
SYNOPSIS The efficacy of diclofenac sodium, a potent prostaglandin inhibitor, in patients with acute migraine attacks in a double‐blind placebo‐controlled study involving 86 migraine patients. Forty‐six patients with acute migraine attacks were treated with intramuscular injection of 75 mg diclofenac sodium, and another group of forty patients with intramuscular injection of paracetamol. Partial or complete relief of pain and other symptoms of acute migraine attack was achieved within 10 minutes after treatment in the diclofenac sodium group and within 32 minutes in the paracetamol group. Complete relief of attack was achieved within 30 minutes after diclofenac sodium in 40 patients (88%) compared to 7 patients (17.5%) of the paracetamol group (P<0,001). Five of the patients treated with diclofenac sodium needed a second injection for complete relief of pain during the 2‐to‐4 hour follow‐up period. Side effects were rare and minimal. In conclusion, diclofenac sodium administered intramuscularly is a very effective drug in treating acute migraine attacks.