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Transcranial Doppler (TCD) After Nitroglycerin in Migraine Without Aura
Author(s) -
Zanette Elietta M.,
Agnoli Alessandro,
Cerbo Rosanna,
Chiarotti Flavia,
Roberti Cinzia,
Buzzi M. Gabriella,
Fieschi Cesare
Publication year - 1991
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1991.hed3109596.x
Subject(s) - aura , transcranial doppler , nitroglycerin (drug) , migraine , medicine , anesthesia , migraine with aura , cardiology
SYNOPSIS Nitroglycerin, a vasodilating agent, was administered sublingually in migraine without aura patients andin healthy volunteers. Systolic, diastolic and time‐mean flow velocity and pulsatility index, were measuredby transcranial Doppler sonography in the major intracranial arteries before and after nitroglycerinadministration. Following nitroglycerin administration, a significant decrease in systolic and time‐meanvelocity and pulsatility index was observed in migraine patients, whereas in control subjects onlytime‐mean velocity decreased significantly. Based on those findings we hypothesize a more markedresponsiveness to nitroglycerin in migraine patients as compared to healthy subjects.