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Myocardial Ischemia Related to Ergot Alkaloids: A Case Report and Literature Review
Author(s) -
Galer Bradley S.,
Lipton Richard B.,
Solomon Seymour,
Newman Lawrence C.,
Spierings Egilius L.H.
Publication year - 1991
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1991.hed3107446.x
Subject(s) - methysergide , ergotamine , medicine , headaches , ischemia , myocardial ischemia , migraine , cluster headache , cardiology , anesthesia , surgery , serotonin , receptor
SYNOPSIS Ergotamine tartrate and methysergide are widely used headache treatments with important vasoconstrictive properties. We report a 31‐year‐old man with cluster headaches who developed severe, prolonged myocardial ischemia following combination therapy with ergotamine tartrate and methysergide. We reviewed the cardiovascular complications of each agent alone and in combination. Given the pharmacologic similarity of these agents, we propose that they may have additive or synergistic cardiac toxicity, at least in vulnerable individuals. We recommend caution when these agents are used together.