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Flunarizine Plasma Concentrations and Side Effects in Migraine Patients
Author(s) -
Albani Fiorenzo,
Baldrati Anna,
Cortelli Pietro,
Riva Roberto,
Baruzzi Agostino
Publication year - 1990
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1990.hed3006369.x
Subject(s) - flunarizine , migraine , plasma concentration , sedation , anesthesia , medicine , drug , side effect (computer science) , plasma levels , pharmacology , computer science , programming language , calcium
SYNOPSIS Flunarizine plasma concentrations and side effects were evaluated in migraine patients during a 3 month course of prophylactic treatment. Plasma concentrations did not correlate with daily dose (in mg/kg). Mean flunarizine levels were higher in patients showing sleepiness or sedation. Weight gain was independent of plasma concentrations. Future clinical trials of flunarizine should be supported by drug monitoring in order to clarify the relationship between plasma levels and drug effects.