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Low Brain Magnesium in Migraine
Author(s) -
Ramadan N.M.,
Halvorson H.,
VandeLinde A.,
Levine Steven R.,
Helpern J.A.,
Welch K.M.A.
Publication year - 1989
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1989.hed2909590.x
Subject(s) - migraine , magnesium , in vivo , magnetic resonance imaging , cortical spreading depression , nuclear magnetic resonance , mechanism (biology) , medicine , chemistry , anesthesia , biology , physics , radiology , microbiology and biotechnology , organic chemistry , quantum mechanics
SYNOPSIS Brain magnesium was measured in migraine patients and control subjects using in vivo 31‐PhosphorusNuclear Magnetic Resonance Spectroscopy, pMg and pH were calculated from the chemical shifts between Pi, PCr and ATP signals. Magnesium levels were low during a migraine attack without changes in pH. We hypothesize that low brain magnesium is an important factor in the mechanism of the migraine attack.