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Flow Cytometric Analysis of Lymphocyte Subsets in Peripheral Blood of Chronic Headache Patients
Author(s) -
GilmanSachs Alice,
Robbins Lawrence,
Baum Linda
Publication year - 1989
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1989.hed2905290.x
Subject(s) - flow cytometry , cytotoxic t cell , immunology , immune system , major histocompatibility complex , peripheral blood mononuclear cell , inducer , t lymphocyte , lymphocyte subsets , peripheral blood , lymphocyte , rosette (schizont appearance) , biology , medicine , cd8 , gene , genetics , in vitro
SYNOPSIS Lymphocyte subsets from 5 groups of patients with different types of chronic headaches were analyzed by flow cytometry to determine the number of cells bearing the following markers: T11 (E‐rosette receptor), T3 (total T cells), T4 (T‐helper/ inducer cells), T8 (T‐cytotoxic/suppressor cells), B1 (B‐cells), NKH‐1 (Natural killer cells), 12 (Class II histocompatibility anti‐gens, monomorphic determinants) and Mo2 (monocytes). In 4 of 5 of these groups, the absolute number of T8 lymphocytes was significantly lower than that of the control group. In addition, the T4:T8 ratio was higher in these 4 groups. These findings may suggest a relationship between the immune system and the cause of chronic headaches.