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Effect of Prophylactic Administration of Nimodipine in Patients with Migraine
Author(s) -
Stewart D.J.,
Gelston A.,
Hakim A.
Publication year - 1988
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1988.hed2804260.x
Subject(s) - nimodipine , placebo , medicine , migraine , headaches , anesthesia , statistical significance , prophylactic treatment , placebo group , surgery , calcium , alternative medicine , pathology
SYNOPSIS The prophylactic effect of nimodipine in the treatment of migraine headache was assessed in a prospective, placebo‐controlled, double‐blind trial. Twenty‐six patients were studied during a 3‐month experimental period (placebo vs nimodipine) following a 1‐month period during which all patients received placebo. Results were tabulated using a “headache index”. A trend in favour of a beneficial nimodipine effect on the headache index was demonstrated which achieved statistical significance during one month of the follow‐up period. A similar trend with respect to the overall number of headaches was demonstrated and achieved statistical significance during two months of the follow‐up period. We conclude that nimodipine is a potentially useful agent in the prophylaxis of migraine headache.