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Classic Migraine and Intercalated Seizures in a Young Woman: Efficacy of Flunarizine
Author(s) -
Narbone Maria Carola,
D'Amico Domenico,
Perri Raoul
Publication year - 1988
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1988.hed2803209.x
Subject(s) - flunarizine , migraine , electroencephalography , epilepsy , medicine , prodrome , anesthesia , ictal , pediatrics , psychology , psychiatry , psychosis , calcium
SYNOPSIS A case of a young woman suffering from both migraine and epilepsy is reported. Since the age of 28, she complained of classic migraine attacks and of generalized or partial seizures. The seizures often intercalated themselves between the visual prodrome and the painful phase of her attacks. She came to our observation at the age of 31. Neurological examination, laboratory work and CT‐scan were normal. The EEG showed an asymmetry of the background activity between the two hemispheres and medium‐voltage sharp waves, not blocking upon eye opening, in the left parieto‐temporel leads. Flunarizine was added to her anti‐convulsant therapy. It remarkably reduced the migraine attacks and controlled the intercalated seizures. After one year, flunarizine was discontinued and two intercalated seizures occurred four months later. The efficacy of flunarizine and its hypothetical mechanism of action in such a clinical condition is discussed.