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Identification of Blood Leukotrienes in Classical Migraine
Author(s) -
Gazzaniga P. P.,
Ferroni R,
Lenti L.,
Lombardi D.,
Mina C.,
Pulcinelli F.M.,
Rizzo P.A.,
Pontieri G. M.
Publication year - 1987
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1987.hed2704211.x
Subject(s) - leukotriene , epinephrine , migraine , pathogenesis , platelet , platelet aggregation , histamine , medicine , chemistry , endocrinology , pharmacology , asthma
SYNOPSIS In five patients affected by classical migraine a longitudinal study was performed, dealing with the in vitro parameters of platelet aggregation, during prodromal, attack, post‐attack and interval phases. These patterns were compared with the analysis of blood leukotrienes, carried out by use of analytical reversed phase HPLC. Presence of leukotriene C 4 (LTC 4 ) during prodromal and attack phases, corresponded to a transient inhibition of epinephrine‐induced aggregation. Recovery towards normal or increased values of platelet aggregation occurred during both post‐attack and interval phases, which were accompanied by the presence in blood of 5–12 di‐hydroxyeicosatetraenoic acid (5–12 DHETE) and/or leukotriene B 4 (LTB 4 ) respectively, and by their subsequent metabolic breakdown products. Hypotheses on the role of leukotrienes in the pathogenesis of migraine are discussed.