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Plasma Methionine Enkephalin. Increased Levels During a Migraine Episode
Author(s) -
Mosnaim Aron D.,
Chevesich Jorge,
Wolf Marion E.,
Freitag Frederick G.,
Diamond Seymour
Publication year - 1986
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1986.hed2606278.x
Subject(s) - migraine , medicine , neuropeptide , endocrinology , migraine disorders , plasma concentration , methionine , plasma levels , endorphins , beta endorphin , neuropeptide y receptor , met enkephalin , anesthesia , enkephalin , chemistry , opioid , receptor , biochemistry , amino acid
SYNOPSIS Plasma methionine‐enkephalin (MET) levels in migraine patients, either during an attack or when pain‐free, are statistically significantly higher than in matched controls; this is also true when comparing the classical and nonclassical migraine subpopulations with the control group. Individual patients consistently presented lower MET plasma concentrations in the pain‐free period than during the acute headache, with some subjects showing values falling within the range of controls. Platelet neuropeptide content was similar in patients and controls, irrespective of plasma MET levels. These results indicate that increased plasma MET concentrations are associated with the occurrence of a migraine episode and suggests that they are not a constant characteristic of migraineurs.