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Decreased Thromboxane Production in Migraine Patients During Headache‐Free Period
Author(s) -
KeinänenKiukaanniemi S.,
Kääpä P.,
Saukkonen A.L.,
Viinikka L.,
Ylikorkala O.
Publication year - 1984
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1984.hed2406339.x
Subject(s) - migraine , thromboxane b2 , platelet , thromboxane , arachidonic acid , thromboxane a2 , medicine , metabolite , endocrinology , chemistry , biochemistry , enzyme
SYNOPSIS To study the role of the proaggregatory, vasoconstrictory thromboxane A 2 (TxA 2 ) in migraine, the plasma levels of Thromboxane B 2 (TxB 2 ), the stabile metabolite of TxA 2 , were measured from 14 adults and 8 children with migraine during the attack‐free interval. In addition, the platelets' capacity to generate TxB 2 during spontaneous clotting was studied. The plasma TxB 2 concentrations were lowered in the adult migraine patients. Also the platelets' capacity to produce TxB 2 was reduced in migraine children and in adults with classic migraine. The decreased platelet TxA 2 synthesis in the attack‐free period of migraine patients may reflect a deficient pool of platelet arachidonic acid, the precursor of TxA 2 , perhaps as a result of increased consumption during migraine attacks.