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The Effect of Ergotamine on Prostaglandin Formation in Guinea Pig‘s Ear Slices
Author(s) -
Zijlstra Frederik J.,
Spierings Egilius L.H.,
Vincent J. Eric
Publication year - 1980
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1980.hed2006305.x
Subject(s) - ergotamine , guinea pig , arachidonic acid , prostaglandin , incubation , phospholipase a2 , chemistry , endocrinology , medicine , biology , biochemistry , migraine , enzyme
SYNOPSIS We have studied the effect of ergotamine tartrate (10 −7 and 10 −5 M) on prostaglandin (PG) formation in guinea pig's ear slices because of the suggested role of PGs in the pathophysiology of the migraine attack. The ear slices were incubated with arachidonic acid (AA) and the amount of different PGs (6‐keto‐F 1a , F 2a , E 2 , D 2 and A 2 ) in the incubation medium was determined. The results indicate that ergotamine is an inhibitor of PG synthesis and that it probably affects either the phospholipase A 2 or the cyclo‐oxygenase activity.