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The Biochemistry of Migraine
Author(s) -
Bruyn G.W.
Publication year - 1980
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1980.hed2005235.x
Subject(s) - migraine , histamine , nociception , neuroscience , inhibitory postsynaptic potential , serotonin , tyramine , medicine , chemistry , endocrinology , psychology , receptor
SYNOPSIS In the stereotyped, transient and paroxysmal triad of autonomic, vascular and nociceptive dysfunction, precipitated by non‐specific factors, known as the migraine attack certain biochemical mediators appear to occupy key‐positions in the chain of pathomechanic events occurring at the neural and humoral interface.Of these are reviewed: histamine and serotonin (inhibitory at the microvascular level), substance P and the kinins (excitatory at the nociceptive neural level), tyramine as an a‐adrenergic activator, and prostaglandins as humoral agents acting on certain cell‐membranes. Anatomical, clinical and biochemical arguments are marshalled to bring the neurogenic origin of the migraine attack into focus, in particular at hypothalamic level.