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Comparative Trial of Tenormin (Atenolol) and Inderal (Propranolol) in Migraine
Author(s) -
Stensrud Per,
Sjaastad Ottar
Publication year - 1980
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1980.h2004006.x
Subject(s) - atenolol , propranolol , migraine , placebo , medicine , anesthesia , migraine disorders , blood pressure , alternative medicine , pathology
SYNOPSIS Atenolol, 50 mg, b.i.d., and propranolol, 80 mg b.i.d., were given to 28 patients with a presumed diagnosis of migraine, in a placebo‐controlled double‐blind cross‐over study, where each period lasted 6 weeks. In the total material, atenolol was significantly better than placebo in reducing attacks, whereas propranolol showed no definite such effect. In seven patients, the number of headache days was remarkably high (average: 22 headache days in 42 days), which may indicate that they have been inappropriately included in the material or have recorded interparoxysmal headache in addition to attacks. If these patients are excluded, the attack‐reducing effects of both propranolol and atenolol are significant and of equal magnitude.