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Controlled Trials of Cimetidine in Migraine and Cluster Headache
Author(s) -
Anthony M.,
Lord G.D.A.,
Lance J.W.
Publication year - 1978
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1978.hed1805261.x
Subject(s) - cimetidine , histamine , migraine , cluster headache , antagonist , histamine h1 receptor , medicine , headaches , pharmacology , receptor antagonist , histamine h2 receptor , anesthesia , receptor , psychiatry
SYNOPSIS Controlled double‐blind trials of the histamine H 2 ‐receptor antagonist, cimetidine, alone and in combination with the histamine H 1 ‐receptor antagonist, chlorpheniramine, in 24 patients with migraine and 20 patients with cluster headache, showed that these agents were ineffective in prophylaxis. The reason for this may lie in the fact that induced intracellular histamine does not act via receptors and does not necessarily negate the hypothesis that histamine plays a role in the pathogenesis of vascular headaches.