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The Dopaminergic and Noradrenergic Blockades:
Author(s) -
Lechin Fuad,
Der Dijs Bertha,
Lechin Ernesto,
Peña Francisco,
Bentolila Ana
Publication year - 1978
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1978.hed1802069.x
Subject(s) - blockade , dopaminergic , headaches , propranolol , medicine , dopamine , anesthesia , norepinephrine , surgery , receptor
SYNOPSIS In accordance with a double‐blind pilot study carried out in 60 headache patients, it was found that dopaminergic blockage was able to maintain the improvement induced by d‐amphetamine plus propranolol (AP)‐treatment as well as to relieve significantly those patients not improved by the amphetaminic treatment. The addition of noradrenergic blockade provoked the total disappearance of the improvement in some (including those relieved by AP‐treatment), whereas it induced a significant further increment of the relief in other patients. These results suggest that there are two kinds of headache patients, those improved by the enhancement and those improved by the blockade of the noradrenergic system. The demonstrated fact that the dopaminergic blockade was able to relieve both types of headaches indicates that a common factor, located at the dopamine‐system level, is shared by the pathophysiologic mechanisms of both types ot headaches.