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Humoral and Hormonal Changes in Menstrual Migraine
Author(s) -
Nattero G.,
Bisbocci D.,
Bottini A.,
Brandi G.,
Griffa P.G.,
Lisino F.,
Ansini A.,
Ceresa F.
Publication year - 1977
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1977.hed1701023.x
Subject(s) - migraine , aldosterone , medicine , plasma renin activity , endocrinology , circadian rhythm , menstrual cycle , hormone , menstrual period , renin–angiotensin system , sodium , physiology , blood pressure , chemistry , organic chemistry
SYNOPSIS Circadian plasma levels of aldosterone, renin activity, cortisol, sodium and potassium were studied during the migraine attack and headache‐free periods in ten women with menstrual migraine. Aldosterone dropped at the onset of an attack in all cases, producing an inverted profile when plotted at two‐hourly intervals over a 24‐hour period and compared with aldosterone levels during a headache‐free period. Renin activity and cortisol levels were normal during migraine and headache‐free periods and potassium and sodium were normal during the migraine attack. A possible explanation for the fall in aldosterone during the attack phase is increased conjugation in the liver due to increased hepatic blood flow.