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RESERPINE FOR MIGRAINE PROPHYLAXIS
Author(s) -
Nattero G.,
Lisino F.,
Brandi G.,
Gastaldi L.,
Genefke I. Kemp
Publication year - 1976
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.1976.hed1504279.x
Subject(s) - reserpine , migraine , medicine , vasoactive , serotonin , anesthesia , norepinephrine , pharmacology , dopamine , receptor
SYNOPSIS Because of the role of monoamines in the genesis of migraine and the pharmacologic action of reserpine, we have used this substance in prophylactic treatment of migraine for 10 years on 300 patients. 1 Intravenously administered reserpine in a dose of 0.2 mg every second or third day for a period of 6‐8 weeks was employed. Statistically significant improvement in severe migraine was obtained. A double blind clinical trail of this method of therapy carried out in Turin and Copenhagen confirmed the efficacy of reserpine in the treatment of severe migraine if given in appropriate doses. No side effects were observed. It is suggested that the intravenous administration at regular intervals of small doses of reserpine depletes norepinephrine and/or serotonin, these vasoactive substances are not released at the time of a migrainous attack.