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17 Osteoprotegerin and Bone Turnover Markers in Serum of Dialysis Patients
Author(s) -
Rus I,
AvberšekLužnik I,
Marc J
Publication year - 2005
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/j.1526-0968.2005.222_17_17.x
Subject(s) - medicine , osteoprotegerin , bone remodeling , endocrinology , osteocalcin , alkaline phosphatase , renal osteodystrophy , dialysis , kidney disease , enzyme , biochemistry , chemistry , receptor , activator (genetics)
Recent studies have shown high circulating levels of osteoprotegerin (OPG), one of the local regulators of bone remodelling in renal osteodystrophy. For non‐invasive bone turnover assessment several serum markers are used, therefore we investigated the relationship between OPG and some of established serum markers. Methods The 33 dialysis patients (age: 56.6 ± 12.2 years) and 20 control individuals (age: 56.0 ± 20.6 years) were included in this study. Dialysis patients were divided according PTH serum levels (below/above 300 pg/mL) into low ( N = 23) and high ( N = 10) PTH subgroups. Bone alkaline phosphatase (BALP), osteocalcin (OC), tartarate‐resistant acid phosphatase 5b (TRAP 5b) and OPG were measured in all serum samples by specific immunoassays, using commercially available reagent kits. Results Serum OPG levels in the whole group of dialysis patients (679.0 ± 213.0 pg/mL) were approximately two times higher than in controls (337.1 ± 103.0 pg/mL). The difference in OPG levels between low (708.8 ± 219.3 pg/mL) and high (613.3 ± 191.9 pg/mL) PTH subgroup was not significant ( P = 0.223). In contrast, serum levels of OC and TRAP 5b differed significantly ( P < 0.045) and BALP near the limit of significance ( P = 0.065). We observed nonsignificant correlation between OPG and measured bone markers in both PTH subgroups (r < 0.18). The relation between OPG and PTH was also inverse and nonsignificant (r < −0.365). Conclusions These results indicate that OPG alone does not match the requirements of a useful biochemical marker for differentiation between dialysis patients with low and high bone turnover. However, established serum bone markers could serve clinicians in diagnosing specific types of renal osteodystrophy.