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Comparative Analysis Between Dextran Sulfate Adsorption and Direct Adsorption of Lipoproteins in their Capability to Reduce Erythrocyte Adhesiveness/Aggregation in the Peripheral Blood
Author(s) -
Schechner V,
Berliner S,
Shapira I,
Justo D,
Hershcovici T,
Zeltser D,
Beigel Y
Publication year - 2004
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1111/j.1526-0968.2004.00105.x
Subject(s) - medicine , adsorption , peripheral blood , sulfate , dextran , erythrocyte aggregation , peripheral , chromatography , immunology , hematocrit , organic chemistry , chemistry
The purpose of this study was to compare the degree of erythrocyte adhesiveness/aggregation (EAA) reduction of two low‐density lipoprotein (LDL) apheretic procedures, namely direct adsorption of lipoproteins (DALI) and dextran sulfate adsorption (DSA). A significant ( P < 0.001) reduction of EAA was noted in six hypercholesterolemic patients who underwent a total of 40 apheretic sessions and no difference was noted in the degree of EAA reduction by the two techniques. Thus, being a real‐time and point‐of‐care test, the erythrocyte adhesiveness/aggregation test can be applied in relevant situations of acute ischemia, where therapeutic LDL apheresis could improve the hemorheology of individuals with increased concentrations of cholesterol and inflammatory sensitive proteins.