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Tri‐Leaflet Valve Design With a Purge Flow for Heart‐Assist Devices: An In Vitro Optimization Study
Author(s) -
Timmel Tobias,
Seshadri Santhosh,
Goubergrits Leonid,
Affeld Klaus,
Kertzscher Ulrich
Publication year - 2012
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2011.01308.x
Subject(s) - purge , flow (mathematics) , pulsatile flow , backflow , heart valve , blood flow , biomedical engineering , surgery , cardiology , mechanics , materials science , medicine , engineering , mechanical engineering , physics , waste management , inlet
The objective of this study is to assess the effect of a purge flow on valves of pulsatile heart‐assist devices. Clinical applications of these devices are still limited because of frequent thromboembolic complications. These complications often originate at the valves and the unavoidable flow separation regions that are found behind the leaflets. The flow separations cause a long residence time of blood that is considered particularly detrimental. To solve this problem, a valve with a purge flow is proposed. A purge flow is a jet, which is separated from the main blood flow and directed behind the leaflets into the sinus to flush it. Even though the purge flow does not prevent a flow separation, it shortens the residence time of the blood in the sinus. Thus, the purge flow improves the periodic washout of the blood in the region of flow separation. The complex purge flow was investigated in a tri‐leaflet valve. The geometrical parameters of the valve were varied systematically. A statistical technique—the Taguchi method—was used to reduce the number of investigated models to 12. The flows through the resulting valve models were numerically simulated and analyzed. The evaluated models with the best results were subsequently investigated experimentally using different methods: hemodynamic tests in a valve tester and flow visualization using the dye washout method. It was shown that the purge flow can effectively wash out the sinus. Therefore, the purge flow valve reduces the potential of a thrombus formation normally associated with the valve.