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Development and In Vitro Characterization of a New Artificial Flow Channel
Author(s) -
Wendt Daniel,
Stühle Sebastian,
Hou Guojun,
Thielmann Matthias,
Tsagakis Konstantinos,
Wendt Hermann,
Jakob Heinz,
Kowalczyk Wojciech
Publication year - 2011
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2010.01166.x
Subject(s) - cardiopulmonary bypass , particle image velocimetry , catheter , computer science , heart valve , cardiac valve , medicine , flow (mathematics) , biomedical engineering , channel (broadcasting) , risk analysis (engineering) , intensive care medicine , surgery , cardiology , physics , mechanics , turbulence , computer network
To date, cardiac valve diseases are considered as a major public health problem and most frequently, the aortic valve is affected. To treat high‐risk patients, catheter‐based techniques have been developed recently, avoiding open heart surgery and/or cardiopulmonary bypass. Although these sophisticated and rapidly emerging catheter‐based technologies do allow a minimally invasive treatment option of high‐risk patients on the one hand, further developments and in vitro testing under physiological conditions are necessary, on the other hand, in order to further optimize them for clinical routines. Therefore, we present the concept of a new multifunctional flow channel, offering (i) the possibility of transapical access; (ii) the simulation of physiological flow conditions; and (iii) the evaluation of the fluid flow by 2D particle image velocimetry within a wide range of parameters.