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Use of In Vivo Insert Molding to Form a Jellyfish Valve Leaflet
Author(s) -
Kishi Ayumi,
Isoyama Takashi,
Saito Itsuro,
Miura Hidekazu,
Nakagawa Hidemoto,
Kouno Akimasa,
Ono Toshiya,
Inoue Yusuke,
Yamaguchi Sachiko,
Shi Wei,
Abe Yusuke,
Imachi Kou,
Noshiro Makoto
Publication year - 2010
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2010.00997.x
Subject(s) - molding (decorative) , insert (composites) , connective tissue , materials science , mold , biomedical engineering , shrinkage , heart valve , anatomy , composite material , surgery , biology , medicine , pathology
We developed an in vivo insert molding technique to form tissue‐derived biomaterials into the desired shape, and with sufficient strength and durability, for use in artificial organs. Molds of acrylic resin with inserted velour cloth were implanted under the skin of goats to form a circular leaflet for a jellyfish valve. The valve leaflets were successfully produced in the molds after 17–60 days. Dense connective tissue covered the velour cloth, and loose connective tissue was formed within it. Tissue was radially formed from the hole in the mold. The tissue was simultaneously formed and shrunk. It is necessary to increase the connected portion between the tissue inside and outside the mold so that the tissue can completely cover the inserted materials without shrinkage.