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Application of Polycaprolactone as an Anti‐Adhesion Biomaterial Film
Author(s) -
Lo HsienYi,
Kuo HsuanTing,
Huang YiYou
Publication year - 2010
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2009.00949.x
Subject(s) - polycaprolactone , adhesion , cecum , biomaterial , scanning electron microscope , biomedical engineering , materials science , tissue adhesion , surgery , chemistry , medicine , composite material , polymer
Adhesions are unavoidable consequences of surgery and other trauma. How to prevent the adhesions remains a big issue in healthcare system. The objective of this study is to test the efficacy of polycaprolactone (PCL) films as physical barriers in reducing postoperative intra‐abdominal adhesions in the rat cecum‐abdominal wall model. PCL is quite cheap compared with the agents recently used in the market. The fabrication method is also very easy to perform. Scanning electron microscope (SEM) showed multiple pores over upper and bottom surfaces but too small to permit cells to migrate from one surface onto another surface. Those pores were proven to be not interconnected. The PCL film did not show any evidence of cytotoxic effects as it did not induce any significant increase in cytoplasmic lactate dehydrogenase release from the NIH3T3 cells that it came in contact with. In animal studies, the PCL films led to fewer adhesions than Seprafilm in rat adhesion model. PCL films were efficacious in reducing postoperative intra‐abdominal adhesion formation in rat cecum‐abdominal wall models.