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In Vitro and Computational Thrombosis on Artificial Surfaces With Shear Stress
Author(s) -
Corbett Scott C.,
Ajdari Amin,
Coskun Ahmet U.,
NHashemi Hamid
Publication year - 2010
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2009.00930.x
Subject(s) - thrombus , shear stress , thrombosis , computational fluid dynamics , shear rate , blood viscosity , coagulation , materials science , blood clotting , biomedical engineering , shear (geology) , viscosity , composite material , medicine , surgery , cardiology , mechanics , physics
Implantable devices in direct contact with flowing blood are associated with the risk of thromboembolic events. This study addresses the need to improve our understanding of the thrombosis mechanism and to identify areas on artificial surfaces susceptible to thrombus deposition. Thrombus deposits on artificial blood step transitions are quantified experimentally and compared with shear stress and shear rate distributions using computational fluid dynamics (CFD) models. Larger steps, and negative (expanding) steps result in larger thrombus deposits. Fitting CFD results to experimental deposit locations reveals a specific shear stress threshold of 0.41 Pa or a shear rate threshold of 54 s −1 using a shear thinning blood viscosity model. Thrombosis will occur below this threshold, which is specific to solvent‐polished polycarbonate surfaces under in vitro coagulation conditions with activated clotting time levels of 200–220 s. The experimental and computational models are valuable tools for thrombosis prediction and assessment that may be used before proceeding to clinical trials and to better understand existing clinical problems with thrombosis.